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SSRI Antidepressants Have More Side Effects On Seniors

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HealthDay News has reported that new research is suggesting that newer antidepressants like Prozac and Effexor have more side effects on seniors than older antidepressants.

Selective serotonin reuptake inhibitors (SSRIs) are generally considered safe and effective, but a new British study found that older tricyclic antidepressants might be safer for people over the age of 65.

The study looked at 60,000 patients aged 65 to 100 who were diagnosed with depression, and found that seniors on SSRIs had a higher risk of dying, having a stroke, failing, breaking a bone, and suffering seizures when compared with those not taking any antidepressants. The study also found that 10.6 percent of those taking an SSRI died, while only 8 percent of those on tricyclics died, and only 7 percent of those taking no antidepressants died.

Effexor, Remeron, and Desyrel showed the highest risks, and it was noted that the risks were highest in the month after starting an antidepressant, and the month after discontinuing the drug.

There was one important limitation to the findings — tricyclics tended to be prescribed at lower doses than SSRIs, which “can explain at least some of our findings of lower risks associated with [tricyclics],” said study author Carol Coupland, associate professor of medical statistics at the University of Nottingham. She added, however, that “there is some evidence from other studies that low-dose [tricyclics] may be as effective as higher doses in reducing symptoms of depression,” Doctors Lounge reported. disclaimer: This article: SSRI Antidepressants Have More Side Effects On Seniors was posted on Wednesday, August 3rd, 2011 at 7:49 pm at and is filed under Defective Drug Lawsuits.

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