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SSRI Antidepressant Drugs Linked to Reduced bone Formation and an Increased Risk of Bone Fractures

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A group of antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs) reduce bone formation and increase bone fracture risks, according to a new study.

Bone metabolism is affected by osseointegration so researchers took a closer look at the association between SSRIs and the risk of failures in osseointegrated dental implants, wrote HNGN. 

This retrospective cohort study was conducted on patients treated with dental implants from January 2007 to January 2013. A total of 916 dental implants in 490 patients (94 implants on 51 patients using SSRIs) were used to estimate the risk of failure associated with the use of SSRIs. The scientists analyzed data from cox proportional hazards, general estimates involving equations models and Kaplan-Meier analysis, ScienceBlog reported.

After three to 67 months of follow-up, 38 dental implants failed in and 784 succeeded in the group of participants not taking an SSRI. In the group of participants taking an SSRI drug, 10 dental implants failed and 84 succeeded, according to ScienceBlog.

The International and American Associations for Dental Research (IADR/AADR) published the results of the study the OnlineFirst portion of the Journal of Dental Research in a report titled, “SSRIs and the Risk of Osseointegrated Implant Failure – A Cohort Study,” HNGN reported.

Researchers determined that SSRI use was associated with an increased risk of dental implants failure (HR= 2?31; P< 0?01). The failure rate of SSRI non-users was 4.6 percent compared with 10.6 percent in SSRI users, according to ScienceDaily.

Secondarily, small implant diameters (?4mm) (P=0?01), bone augmentation (P=0?04) and smoking habits (P<0?01) were also associated with an increased risk of implant failure. The study was, however, limited due to researchers’ inability to obtain drug compliance dose and treatment period from the files of patients, ScienceBlog reported.

SSRI use has been linked to many illnesses and adverse health events including upper-gastrointestinal bleeding, an increased autism risk in pregnant women, heart problems, weight gain and stroke. The number of prescriptions for SSRIs – including Celexa, Lexapro, Prozac, Paxil and Zoloft – rose nearly 400 percent from 1988 to 2011, when Time magazine reported on the sharp increase.

U.S. Centers for Disease Control and Prevention (CDC) statistics show 9.1 percent of American adults suffer from depression at any given time. Antidepressant prescriptions are more common than the disease itself (11 percent) and are often prescribed for conditions other than depression, such as anxiety disorders, pain and menopausal symptoms, according to Time. disclaimer: This article: SSRI Antidepressant Drugs Linked to Reduced bone Formation and an Increased Risk of Bone Fractures was posted on Tuesday, September 9th, 2014 at 12:29 pm at and is filed under Defective Drug Lawsuits.

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